Determination of Laterality in the Rabbit Embryo: Studies on Ciliation and Asymmetric Signal Transfer
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Connexin26-mediated transfer of laterality cues in Xenopus
A cilia-driven leftward flow of extracellular fluid breaks bilateral symmetry in the dorsal midline of the neurula stage vertebrate embryo. The left-specific Nodal signaling cascade in the lateral plate mesoderm (LPM) is key to asymmetric morphogenesis and placement of organs during subsequent development. The nature of the initial asymmetric cue(s) as well as the transfer of information from t...
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